亚专业组团队：
方向带头人及团队成员：袁忠明、黄荣忠、李春、吕安康
本方向主要工作：主要开展工作为痴呆和认知障碍的早期诊断及治疗、老年抑郁症的风险评估及规范治疗、老年睡眠障碍的综合诊治、老年人癫痫的病因及个体化治疗。同时开展老年脑卒中的防治工作，减少其发病率及合并症，提高老年人的生活质量，延长寿命。
本方向特色：本方向团队通过采取症状评估、神经心理量表、生物标记物和影像学为一体的诊断技术服务于老年记忆障碍的患者，积累了丰富的经验，为早期诊断、鉴别痴呆和认知障碍起到了积极的促进作用。开展老年脑卒中的防治，通过多重防线，降低老年脑卒中患者的发病率、减少其并发症的发生，尽可能使老年患者远离脑卒中发病危险。
亚专业组团队科研：
抑郁、认知障碍方向科研成果：发表SCI论文13篇，申请并主持国家自然科学基金项目一项。
1. Tang M, Huang H, Li S, Zhou M, Liu Z, Huang R, Liao W, Xie P, Zhou J. Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress. Transl Psychiatry. 2019 Oct 17;9(1):260.
2. Xie H, Huang H, Tang M, Wu Y, Huang R, Liu Z, Zhou M, Liao W, Zhou J. iTRAQ-Based Quantitative Proteomics Suggests Synaptic Mitochondrial Dysfunction in the Hippocampus of Rats Susceptible to Chronic Mild Stress. Neurochem Res. 2018 Dec;43(12):2372-2383.
3. Mao Q, Zhang L, Guo Y, Sun L, Liu S, He P, Huang R, Sun L, Chen S, Zhang H, Xie P. Identification of suitable reference genes for BDV-infected primary rat hippocampal neurons. Mol Med Rep. 2016 Dec;14(6):5587-5594.
4. Zhang H, He P, Huang R, Sun L, Liu S, Zhou J, Guo Y, Yang D, Xie P. Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. Mol Med Rep. 2016 Nov;14(5):4715-4722.
5. Wang S, Qi Y, Yu L, Zhang L, Chao F, Huang W, Huang R, Li H, Luo Y, Xiu Y, Tang Y. Endogenous nitric oxide regulates blood vessel growth factors, capillaries in the cortex, and memory retention in Sprague-Dawley rats. Am J Transl Res. 2016 Dec 15;8(12):5271-5285.
6. Zhang L, Liu S, Zhang L, You H, Huang R, Sun L, He P, Chen S, Zhang H, Xie P. Real-time qPCR identifies suitable reference genes for Borna disease virus-infected rat cortical neurons. Int J Mol Sci. 2014 Nov 26;15(12):21825-39.
7. Liu X, Bode L, Zhang L, Wang X, Liu S, Zhang L, Huang R, Wang M, Yang L, Chen S, Li Q, Zhu D, Ludwig H, Xie P. Health care professionals at risk of infection with Borna disease virus - evidence from a large hospital in China (Chongqing). Virol J. 2015 Mar 12;12:39.
8. Liu S, Bode L, Zhang L, He P, Huang R, Sun L, Chen S, Zhang H, Guo Y, Zhou J, Fu Y, Zhu D, Xie P. GC-MS-Based Metabonomic Profiling Displayed Differing Effects of Borna Disease Virus Natural Strain Hu-H1 and Laboratory Strain V Infection in Rat Cortical Neurons. Int J Mol Sci. 2015 Aug 17;16(8):19347-68.
9. Zhao M, Sun L, Chen S, Li D, Zhang L, He P, Liu X, Zhang L, Zhang H, Yang D, Huang R, Xie P. Borna disease virus infection impacts microRNAs associated with nervous system development, cell differentiation, proliferation and apoptosis in the hippocampi of neonatal rats. Mol Med Rep. 2015 Sep;12(3):3697-3703.
10. Zhang L, Wang X, Zhan Q, Wang Z, Xu M, Zhu D, He F, Liu X, Huang R, Li D, Lei Y, Xie P. Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China. Arch Virol. 2014 Aug;159(8):1941-9. doi: 10.1007/s00705-013-1971-5.
11. Liu X, Zhao L, Yang Y, Bode L, Huang H, Liu C, Huang R, Zhang L, Wang X, Zhang L, Liu S, Zhou J, Li X, He T, Cheng Z, Xie P. Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells. Virology. 2014 Sep;464-465:196-205.
12. Li D, Lei Y, Deng J, Zhou C, Zhang Y, Li W, Huang H, Cheng S, Zhang H, Zhang L, Huang R, Liu X, Ma L, Wang X, Li J, Xie P. Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro. PLoS One. 2013 Jun 21;8(6):e66623.
13. Huang R, Gao H, Zhang L, Jia J, Liu X, Zheng P, Ma L, Li W, Deng J, Wang X, Yang L, Wang M, Xie P. Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells. PLoS One. 2012;7(9):e44665.
PFK-1关键位点磷酸化改变干扰葡萄糖代谢在博尔纳病毒引起5-HT紊乱和学习记忆障碍中的机制研究 31300137 国家自然科学基金 23万，结题
亚专业组技术有：睡眠监测、TCD+转颈试验检查、肌电图、脑电图、诱发电位、神经传导速度、神经活检、肌肉活检。
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